Win500 with Wine
From The RadioReference Wiki
Software for PSR-500 and PSR-600 from GRE (and Radio Shack rebranded derivatives Pro-106 and Pro-197). Allows full control and configuration of these models, as well as monitoring, logging and audio recording, when used with a compatible USB cable, among many other Win500 features
The software is written by of StarSoft.com. The latest version, as of this writing, is 1.91. Written for use in Microsoft Windows, it requires Windows 2000 or later version. Windows 95,98, etc. are not supported.
Some success in running Win500 under WINE has been reported here.